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What is Foundayo?
About this page. Written by the GLPInfo editorial team with AI assistance from the official sources listed at the end, and approved by the site owner before publication. It has not been reviewed by a named clinician. Published 7 Sep 2026 · next scheduled review 7 Dec 2026.
This page is information, not medical advice. It never tells you which medicine or dose is right for you: those decisions sit with you and a licensed prescriber. Report suspected side effects to FDA MedWatch. Spotted an error? Tell us.
Foundayo is Eli Lilly's orforglipron, the first small-molecule oral GLP-1, FDA-approved on 1 April 2026 for chronic weight management and sold self-pay from $149 a month through LillyDirect. Unlike the Wegovy pill it can be taken at any time of day with no food or water restrictions.
How it works
Orforglipron is a small-molecule GLP-1 receptor agonist rather than a peptide, so the stomach does not degrade it the way it degrades semaglutide; the tablet needs no fasting window and is taken once daily, whole, with or without food.
Doses
Six strengths from 0.8mg through 2.5mg, 5.5mg, 9mg and 14.5mg to 17.2mg, in 30-tablet monthly packs, with increases after at least 30 days at each step as the prescriber judges.
What the trials showed
In ATTAIN-1 (72 weeks, published in the New England Journal of Medicine in 2025), the highest dose produced an average body-weight reduction of 12.4% (27.3lb) among those who completed treatment versus 0.9% with placebo; counting everyone randomised, 11.1% versus 2.1%. That sits below the injections' trial averages, with the usual caveat that cross-trial comparisons are unreliable and no head-to-head has been published.
Side effects and safety
The most common are gastrointestinal (nausea, constipation, diarrhoea, vomiting, indigestion), with pancreatitis, severe gastrointestinal effects leading to dehydration and hypoglycaemia with certain diabetes medicines among the serious risks, and the class boxed warning on thyroid C-cell tumours. Report suspected side effects to FDA MedWatch.
What it costs today
First-month all-in prices for Foundayo at the 0.8mg starting dose currently start from $149 at LillyDirect across the channels we compare, read 6 Sep 2026. Compare all Foundayo channels or see the 12-month true cost.
Frequently asked questions
How much does Foundayo cost?
$149 (0.8mg and 2.5mg), $199 (5.5mg) and $299 (9mg and above) through LillyDirect and TrumpRx, with promotional pricing on some doses to 31 December 2026, plus any telehealth membership fee. Live comparison.
Foundayo or the Wegovy pill?
Both are daily tablets; Foundayo has no food or water rules while the Wegovy pill must be taken fasted with a 30-minute wait, and their trial averages and prices differ. The choice is clinical: talk to a prescriber.
Is Foundayo covered by Medicare?
Eligible Medicare members can obtain it for $50 a month under the GLP-1 Bridge to the end of 2027: details.